Biomarkers for navigating autoimmune health challenges - DAO, LPS and Zonulin

3 Bio-markers are Potential Game Changers for Autoimmune Sufferers

This year has already flown by, I can’t believe we are in the third month already! I have many things in the works to share with you and have been eager for reliable internet service to share these fascinating diagnostic testing options with you.  Especially for those on that auto-immunity journey and those on that health journey roller coaster which seems to have wheels spinning in circles…

I’ll cut to the chase – DAO, LPS and Zonulin – Have you heard of them?  Do you know their significance?  Let me give a brief, and I mean brief, overview of what they are and why they are significant.

What are they?

DAO – Diamine Oxidase is primarily secreted in the digestive tract and helps set the stage for a healthy environment in the digestive tract.   Do you have any guesses as to one of the things which happens when someone has low DAO?  If you guessed an adverse environment with an unhealthy microbiome you guessed correct!

LPS – Lipopolysaccharide is also primarily located in the gut.  It is an endotoxin which comes about as your body is fighting bacteria. When we find this in the blood that tells us it is no longer confined in the digestive tract, rather has made its way into our system!

Zonulin – (this is one you may have heard about!) Dr. Alessio Fasano, from Italy, is responsible for discovering the role of this fascinating protein.  Simply put – Zonulin is responsible for opening the tight junctions thereby allowing ‘stuff’ to pass between the cells lining the digestive tract. (If you want to dig deeper and connect some dots on your health journey take a minute and do a quick search at Pubmed: “Fasano Zonulin” and see what turns up 🙂

zonulin illustration

What is the significance?

First, if you haven’t read about the microbiome you may want to check out this post. When our digestive tract has an unhealthy environment that sets the stage for unhealthy flora to take up residence.  In addition what is typically healthy flora can get out of balance and become overpopulated, thereby rendering this once helpful bacteria unhelpful.  Furthermore, this loops back to causing an imbalance so we are left with having an imbalance due to bad environment and a bad environment due to an imbalance – quite the ‘catch 22’ situation!

Next have you heard of antibodies?  Are you familiar with how they come about?  Again, a brief snapshot.  Antibodies are part of the second line of defense in our immune system.  SIgA is the first line involved in the elimination of ‘invaders’.  When these invaders make their way through the lining of the digestive tract(such as when Zonulin opens the door) antibodies come into the scene.  Can you see where this is headed and how this is tied to autoimmunity?

So, we have antibodies getting made and foreign invaders attaching to things where they shouldn’t and our body decides to do what it can to eliminate the offender despite the collateral damage!  It is rather fascinating how we are made!

In addition to all of this histamines and allergies come on the scene…  I said I was going to keep this brief so will leave it at that… Things start to go downhill and the circling domino effect magnifies… Autoimmunity takes hold…

zonulin related disease illustration

What can we do about abnormal findings?

Ah, the million dollar question!!!  I wish I had the answer you are looking for, the fact is there isn’t a one size fits all solution.  This is why those of us with autoimmune conditions often find ourselves spinning in circles trying this protocol and that protocol.  For instance, overall those with MS find Wahls protocol effective, others may find Autoimmune Paleo effective or perhaps SCD(Specific Carbohydrate Diet).  Some may need to tweak and eliminate FodMAPs, Histamines or Nightshades…

We find relief in one area and think we are on the road to healing then have another ‘episode’. What you do for your T1 Diabetic condition may be different than what needs to happen for my T1D son.  This is where these three tests can be very valuable! We know ‘leaky gut’ is associated with autoimmune diseases, so the challenge is to find the breach and fix it.  Is it due to low DAO?  Perhaps its an abundance of Zonulin?  What about a combination of the two?  This is where partnering with a functional practitioner is invaluable. We can help you identify patterns and nuances specific to your situation.   We have to look at all the clues given us, these three markers are just three of the many clues to your ‘health mystery’.

I would love to be able to tell you to take this probiotic, that combination of supplements and you go on your happy way to healing. But, one thing I am 10,000% certain of is we are individuals and a restoration of health must be customized!   Are there similarities and common components to the solutions?  Absolutely!!!

So, can I help you?  Most likely, but it would take looking at your health journey with a fine tooth comb! In the meantime I can recommend a few things which will encourage your body to seek homeostasis:

  • Lifestyle changes which support synchrony with circadian rhythms
  • Plenty of water
  • Real foods
  • Elimination of stress
  • Quality rest
  • Exercise
  • Laughter

The simplest way to come up with a customized plan will take one of two things:

Find a functional practitioner who is passionate about YOUR health challenges. (For instance my  primary interest is in autoimmune challenges, another practitioner may focus on cardiovascular or hormone challenges)  Many do not ‘specialize’ and that is ok, they can still help you formulate a plan!

or

Enroll in functional medicine training and put the pieces of your health back together.

Feel free to contact me with any questions or comments 🙂 And of course you can also take advantage of my free 15 min consult! Best wishes on your journey!

A few references:

Polyamine Oxidase and Diamine Oxidase Activities in Human Milk during the First Month of Lactation.
Bjelakovic L, Kocic G, Bjelakovic B, Najman S, Stojanović D, Jonovic M, Pop-Trajkovic Z.
Iran J Pediatr. 2012 Jun;22(2):218-22.
PMID: 23056889 Free PMC Article

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446060/

 

Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases.
Sturgeon C, Fasano A.
Tissue Barriers. 2016 Oct 21;4(4):e1251384. doi: 10.1080/21688370.2016.1251384. Review.
PMID: 28123927

http://www.tandfonline.com/doi/abs/10.1080/21688370.2016.1251384?journalCode=ktib20

 

Abnormal intestinal permeability and microbiota in patients with autoimmune hepatitis.
Lin R, Zhou L, Zhang J, Wang B.
Int J Clin Exp Pathol. 2015 May 1;8(5):5153-60.
PMID: 26191211 Free PMC Article

https://www.ncbi.nlm.nih.gov/pubmed/26191211

 

Chronic Kidney Disease Induced Intestinal Mucosal Barrier Damage Associated with Intestinal Oxidative Stress Injury.
Yu C, Wang Z, Tan S, Wang Q, Zhou C, Kang X, Zhao S, Liu S, Fu H, Yu Z, Peng A.
Gastroenterol Res Pract. 2016;2016:6720575. doi: 10.1155/2016/6720575.
PMID: 27493661 Free PMC Article

https://dx.doi.org/10.1155/2016/6720575

 

Concomitant Prevalence of Low Serum Diamine Oxidase Activity and Carbohydrate Malabsorption.
Enko D, Meinitzer A, Mangge H, Kriegshäuser G, Halwachs-Baumann G, Reininghaus EZ, Bengesser SA, Schnedl WJ.
Can J Gastroenterol Hepatol. 2016;2016:4893501. doi: 10.1155/2016/4893501.
PMID: 28042564 Free PMC Article

https://www.hindawi.com/journals/cjgh/2016/4893501/

 

Lipopolysaccharide-Induced Middle Ear Inflammation Disrupts the cochlear Intra-Strial Fluid–Blood Barrier through Down-Regulation of Tight Junction Proteins
Jinhui Zhang, Songlin Chen, Zhiqiang Hou, Jing Cai, Mingmin Dong, Xiaorui Shi
PLoS One. 2015; 10(3): e0122572. Published online 2015 Mar 27. doi: 10.1371/journal.pone.0122572
PMCID: PMC4376743

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376743/?report=reader

 

Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease.
Baillie JK, Arner E, Daub C, De Hoon M, Itoh M, Kawaji H, Lassmann T, Carninci P, Forrest AR, Hayashizaki Y; FANTOM Consortium., Faulkner GJ, Wells CA, Rehli M, Pavli P, Summers KM, Hume DA.
PLoS Genet. 2017 Mar 6;13(3):e1006641. doi: 10.1371/journal.pgen.1006641. [Epub ahead of print]
PMID: 28263993 Free Article

http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006641

 

Systemic lipopolysaccharide induces cochlear inflammation and exacerbates the synergistic ototoxicity of kanamycin and furosemide.
Hirose K, Li SZ, Ohlemiller KK, Ransohoff RM. J Assoc Res Otolaryngol. 2014; 15:555–70. doi: 10.1007/s10162-014-0458-8 PMID: 24845404

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141430/?report=classic

 

Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer’s disease.
Jaeger LB, Dohgu S, Sultana R, Lynch JL, Owen JB, Erickson MA, et al.  Brain Behav Immun. 2009; 23:507–17. doi: 10.1016/j.bbi.2009.01.017 PMID: 19486646

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783557/

 

Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat.
Visser JT, Lammers K, Hoogendijk A, Boer MW, Brugman S, Beijer-Liefers S, Zandvoort A, Harmsen H, Welling G, Stellaard F, Bos NA, Fasano A, Rozing J.
Diabetologia. 2010 Dec;53(12):2621-8. doi: 10.1007/s00125-010-1903-9.
PMID: 20853098 Free PMC Article

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20853098/

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Cardiovasular Disease & Diabetes: What is the connection?

The primary health concerns of the late 19th and early 20th centuries were infections diseases.  A shift in adverse health came about after the fortification and enrichment of foods.  Chronic diseases, such as heart disease, cancer and stroke became the prevailing ailments.  These diseases continue to rise, some at alarming rates.  Let’s take a quick look between two prevalent diseases today: Heart Disease and Diabetes. I am going to especially look at the incidents in Nacogdoches County in the State of Texas.  [PDF of this post here]

Some quick stats:

nacogdoches-statistics-cvd-and-diabetes

Is this a sign of malfunction in the bodies of the population?

Maintaining a healthy status requires a homeostasis of the bodily systems. Having healthy levels of glucose in our blood is vital for proper balance. When we eat, signals are sent in our body to aid in the metabolizing of the food we just ate.  Insulin is secreted as a result of some of those signals.  It is the “key” which allows glucose to enter the cells.  Without proper signaling of insulin, glucose cannot enter the cells.  This results in glucose going to other parts of the body.  For our body to function properly it is important to keep glucose levels stable.

When our glucose levels are outside a healthy range it attaches to proteins resulting in diabetes-1724617_1920Advanced Glycation End Products (AGEs).  Excessive AGEs leads to plaque forming in the blood vessels.  One consequence is an impairment of the endothelium which lines the blood vessels.  It is hindered in releasing nitric oxide into the blood stream.  With this compromised cardiovascular system, the body has a difficult time repairing daily wear and tear.  Thus an increase in inflammation.  Heart disease often ensues.

In fact…. Studies have shown an increased incidence of heart disease in the presence of diabetes! 

With a high prevalence of heart disease and diabetes there is a need to understand the role of a proper functioning body. In regards to diabetes and cardiovascular disease the role of glucose balance is of marked importance.  Maintaining proper levels eliminates an exacerbating risk factor for both diabetes and cardiovascular disease.  A body which is in homeostasis is free of disease contrasted with a body where malfunction is present, disease emanates.

What can you do today to ensure a proper functioning body?

Begin practicing the 5 Pillars to Healthy Function!!!

Eat Quality Foods

Get Adequate Sleep

Be Active

Promote Healthy Digestion

Embrace Peace & a Spiritual Connection (Eliminate Stress)

push-ups-888024_1280

Related Research:

A.G.E. Foundation. What are AGEs http://agefoundation.com/age/

CDC Interactive Atlas of Heart Disease and Stroke TablesGeographic Area 2010-2012.

Davis, C., and E. Saltos. (May 1999) “Dietary Recommendations and How They Have Changed Over Time,” America’s Eating Habits: Changes and Consequences, Agriculture Information Bulletin No. 750, USDA, ERS. Chapter 2.

Texas Department of State Health Services. (2012). 2012 Texas Heart Disease and Stroke

Fact Sheets, (2013). Diabetes Prevalence Among Adults BRFSS data Tables

Yamagishi, S-i., Nakamura, N., and Matsui, T. (2016) Glycation and cardiovascular disease in diabetes: A perspective on the concept of metabolic memory. J Diabetes, doi: 10.1111/1753-0407.12475.

9 Tests for Cardiovascular Risk Assessment

If you are reading this chances are you are looking for something more than the standard tests for diagnosing heart disease.  My guess would be you have a desire to get to the underlying causes and factors of your state of health.  I would further venture to say you are also looking at ways to prevent adverse health. I am going to quickly touch on Cardiovascular Assessment in this post.

Heart disease is at the top of the list of health issues in the United States and a growing concern for younger adults. There are several tests available that will dig deeper into the function inside your body and provide us with warnings adverse health is on its way.  These tests are indicators of potential malfunction and impending consequences of the disruption of proper balance.  To get a better look at what is going on ask your healthcare provider for the following tests:

  • Total Cholesterolbody-116585_1280

  • LDL Cholesterol

  • HDL Cholesterol

  • Triglycerides

  • LDL Density Patterns

  • C-Reactive Protein

  • Homocysteine

  • Lp (a)

  • Fibrinogen

Some of these you are probably already familiar with such as the Cholesterol and Triglycerides.  You may be wondering – Why the other tests?  What makes them significant?

C-reactive protein is a protein which indicates inflammation in the body.  This test is a strong risk predictor of future heart attack and/or stroke. It is important to note past or current infections can increase the levels of this protein.

Homocysteine is an amino acid which can injure the lining of blood vessels, thus triggering deposits and atherosclerosis. One study found that men with high homocysteine had 3 times greater risk of heart attack!

Lipoproteins are lipids and proteins that are transported through your bloodstream in ‘packages’. One of these is Lipoprotein(a) [Lp(a)] Lipoprotein(a) is a marker for predicting the severity of future heart disease. This is often strongly influenced by heredity.

Fibrinogen is an important agent in the process of the formation of blood clots.  Again, elevated levels are linked to heart disease and/or stroke.

Each of these areas are affected by our diets and lifestyles.  Making changes in our habits can greatly affect the damage from elevated ‘warning lights’.  Be sure to ask your provider for ways to return a healthy homeostasis in your body!

A few quick tips are:

  • Eat Real foods, avoid packaged and processed foods
  • Get plenty of water daily!
  • Get plenty of rest and relaxation daily!
  • Exercise – the best exercise is the one you will do 🙂 Start low and go slow

As always, comments, questions welcomed and I hope this has been beneficial to you or a loved one!

 

[Relevant Research:

Cantin B, Despres JP, Lamarche B, Moorjani S, Lupien PJ, Bogaty P, Bergeron J, Dagenais GR. Association of fibrinogen and lipoprotein(a) as a coronary heart disease risk factor in men (The Quebec Cardiovascular Study). Am J Cardiol. 2002 Mar 15;89(6):662-6.

Lamarche B, St-Pierre AC, Ruel IL, Cantin B, Dagenais GR, Despres JP. A prospective, population-based study of low density lipoprotein particle size as a risk factor for ischemic heart disease in men. Can J Cardiol. 2001 Aug;17(8):859-65.

Blake GJ, Ridker PM. Novel clinical markers of vascular wall inflammation. Circ Res. 2001 Oct 26;89(9):763-71.

Clarke R, Lewington S, Donald A, Johnston C, Refsum H, Stratton I, Jacques P, Breteler MM, Holman R. Underestimation of the importance of homocysteine as a risk factor for cardiovascular disease in epidemiological studies. J Cardiovasc Risk. 2001 Dec;8(6):363-9.

Matsumoto Y, Daida H, Watanabe Y, Sunayama S, Mokuno H, Yokoi H, Yamaguchi H. High level of lipoprotein(a) is a strong predictor for progression of coronary artery disease. J Atheroscler Thromb. 1998;5(2):47-53.

von Eckardstein A, Schulte H, Cullen P, Assmann G. Lipoprotein(a) further increases the risk of coronary events in men with high global cardiovascular risk. J Am Coll Cardiol. 2001 Feb;37(2):434-9.

Austin MA. Plasma triglyceride as a risk factor for cardiovascular disease. Can J Cardiol. 1998 May;14 Suppl B:14B-17B.

This Blood Test Predicts Death, Even When Everything Else Looks “Great” (Re-blog: Functional Medicine University)

This Blood Test Predicts Death, Even When Everything Else Looks “Great”

Ronald Grisanti D.C., D.A.B.C.O., D.A.C.B.N., M.S.

As I discussed in a recent article, I mentioned the prognostic power of the blood test brain natriuretic peptide (BNP).

Remember there is a 25% increase in death if the BNP is elevated one year after a heart attack. And don’t forget a BNP persistently over 80 pg/mL can be an important indicator of when a more invasive approach is needed such as bypass surgery.

In fact, a BNP twice the normal range can indicate a quadruple risk of death in folks who don’t even have symptoms. There is no other test that has the ability to have this crystal ball power of determining your chances of succumbing to heart failure even if you have no symptoms.

As a brief explanation, BNP is a neuro-hormone made in and released from the heart ventricle. The ventricles of the heart make up the biggest part of the heart muscle that squeezes blood through all the rest of the body. When the ventricles are under too much tension or the work load on the ventricles is too much the BNP goes up.

Basically, if the heart is working overtime to function, the BNP is made in larger quantities to help rescue the heart. The key thing to remember is the BNP will commonly increase long before you have any signs or symptoms that you have any trouble. This is one reason to make sure you keep your blood pressure well within normal levels because it reduces stress on the ventricles

What I find so disturbing is the fact that this is not a new test. It has been around for decades. Can you believe that most cardiologists are not aware of it and if they are, they still don’t order it? blood-1761832_1920

On the other hand knowledgeable “research” cardiologists over ten years ago published in the Journal of the American Medical Association stated the BNP test “was a stronger biomarker for cardiovascular disease and death than the C-Reactive Protein”.

One of the reasons you have not heard more about this test is because there is no drug the pharmaceutical has to treat the elevated BNP.

It is important to understand that a normal BNP according to the traditional medical think should not indicate that you are ok. Studies show that you have a ten-fold risk of early death if you’re in the fourth quintile or in other words in the top ¼ of the normal range, but still in “normal”. Others have shown a 50% increase in death in the fourth quintile while others have shown 20% increase in death above the fourth quintile.

The main point I want to make is to insist your doctor orders the BNP/pro-BNP test to determine if you are heading toward heart failure.

Clearly the BNP has provided information about the risk of dying than no other test can, yet it has been persistently ignored. The leading cardiology journal says, “Serial determinations of BNP levels during outpatient follow-up after acute coronary syndrome predicts the risk of death or new congestive heart failure.

How to treat an elevated BNP

I will now show you natural nutrients that down-regulate the BNP.

The solution is taking real vitamin E which includes four tocopherols and four tocotrienols (alpha, beta, gamma, and delta).

It turns out that the tocotrienols is a precursor to natriuretic hormone and is an essential part of what the body uses to make BNP to help heal the heart. The sad thing is if you ask your cardiologist or other doctor about tocotrienols, most have never even heard of them, even though they are crucial for treating an abnormal BNP. And of course this is not new, as it has been known for over a decade that gamma tocotrienols can lower BNP.

Don’t forget tocotrienols are necessary for fighting cancers making cancer cells commit suicide and stopping metastases. In fact, tocotrienols have been shown to stop the growth of human breast cancer cells, improve blood pressure, prevent abnormal clotting, improve diabetes and much more. Name one medication that does all of that! Instead we have cardiologists and oncologists who have never heard of tocotrienols and do not prescribe this absolutely necessary nutrient to people who need it the most.

One of the other parts of vitamin E, gamma tocopherol also lowers the BNP. And this one as well as the gamma tocotrienol are usually low in patients with coronary heart disease. Be careful that you stay away from plain generic “vitamin E” (which is usually synthetic alpha-tocopherol) which actually lowers the gamma tocotrienols. Always check your multi vitamin and see if it only contains alpha-tocopherol, one of 8 parts of vitamin that you see advertised on TV because they will drive down the other forms of E that are not in it. Get rid of it.

So again what do you do for your elevated BNP ?

First thing is to make sure you have good levels of the eight forms of vitamin E.
{You are probably wondering WHERE do I get a balanced supplement?  Well – here is a linkcapsule that has a great spreadsheet with details of the different supplements Toxinless.com}

BNP also responds to low salt. Change your salt to a potassium salt substitute, available in all grocery store.

The bottom line? The BNP blood test shows risk even when all other tests are normal and even when the person has no symptoms. So after you have ordered your BNP and Pro-BNP, then do not hesitate to take the complete vitamin E and also request your doctor orders a Cardio/ION. Might as well get the best test to get an accurate status on your other heart markers and know what to do to treat any of the abnormal findings.

References

Weidemann A, et al, Hypoxia, via stabilization of the hypoxiainducible factor HIF-1a, is a direct and sufficient stimulus for brain-type natriuretic peptide induction, Biochem J, 409:233-42, 2008 (predicts before symptoms, also useful for cancer hypoxia as well as heart)

  • Rogers Sherry, Total Wellness, Prestige Publishing, May 2013

Lorgis L, et al, High levels of N-terminal pro B-type natriuretic peptide are associated with ST resolution failure after reperfusion for acute myocardial infarction, Q J Med, 100:211-16, 2007 (better predictor than ejection fraction, level over 900 means EKG ST damage not resolved, hypoxia leads to CHF)

James SK, et al, N-terminal pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease: a Global Utilization of Strategies To Open Occluded Arteries (GUSTO)-IV substudy, Circulation 108:275-81, 2003

Tapanainen JM, et al, Natriuretic peptides as predictors of non-sudden and sudden cardiac death after acute myocardial infarction in the beta-blocking era, J Am Coll Cardiol 43; 5:757-63, 2004

Omland T, et al, B-type natriuretic peptide and long-term survival in patients with stable coronary artery disease, Am J Cardiol, 95:24-8, 2005

Morita E, et al, Increased plasma levels of brain natriuretic peptide in patients with acute myocardial infarction, Circulation, 88:82-91, 1993

Morrow DA, NACB Writing Group, National Academy of Clinical Biochemistry laboratory medicine practice guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes, Circulation 115: e356-75, 2007

Omland T, et al, N-terminal pro-B-type type natriuretic peptide and longterm mortality in acute coronary syndromes, Circulation 106:2913-8, 2002

Morrow DA, Prognostic value of serial B-type natriuretic peptide testing during follow-up of patients with unstable coronary artery disease, J Am Med Assoc 294:2866-71, 2005

Richards M, et al, Comparison of B-type natriuretic peptides for assessment of cardiac function and prognosis in stable ischemic heart disease, J Am Coll Cardiol, 47:52-60, 2006

Richards AM, et al, B-type natriuretic peptides and ejection fraction for prognosis after myocardial infarction, Circulation 107:2786-92, 2003

Kragelund C, et al, N-terminal pro–B-type natriuretic peptide and long-term mortality in stable coronary heart disease, New Engl J Med 352:666-75, 2005

Kistorp C, et al, N-terminal pro-brain natriuretic peptide, C-reactive protein, and urinary albumin levels as predictors of mortality and cardiovascular events in older adults, J Am Med Assoc, 293:1609-16, 2005

Harma N, et al, Rapid ventricular induction of brain natriuretic peptide gene expression and experimental acute myocardial infarction, Circulation 92:1558- 64, 1995

Saito H, et al, Gamma-tocotrienol, a vitamin E homolog, is a natriuretic hormone precursor, J Lipid Res, 44;8:1530-5, 2003 (a decade ago!)

Hattori A, et al, Production of LLU-a following an oral administration of gamma-tocotrienols to rats, Biol Pharm Bull 23; 11:1395-7, 2000

Parker RA, et al, Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy3- methyl glutaryl coenzyme A reductase, J Biolog Chem 268; 15:11230-8, 1993 (2 decades ago!)

Inokuchi H, et al, Anti-angiogenic activity of tocotrienols, Biosci Biotechnol Biochem 67:7:1623-27, 2003

Wan Nazaimoon WM, et al, Tocotrienols-rich diet decreases advanced glycosylation end products in non-diabetic rats and improves glycemic control in streptozotocin-induced diabetic rats, Malaysian J Pathol 24; 2:77-82, 2002

Sylvester PW, et al, Role of GTP-binding proteins in reversing the anti-proliferative effects of tocotrienols in preneoplastic mammary epithelial cells, Asia Pacific J Clin Nutr 11 (suppl 7): S452-9, 2002

Steiner M., Vitamin E: more than an antioxidant, Clin Cardiol 16 (4 suppl 1): 116-8, 1993

Newaz MA, et al, Effect of gamma tocotrienols on blood pressure, lipid peroxidation and total antioxidant status in spontaneously hypertensive rats (SHR), Clin Exper Hypert (New York) 21; 8:1297-1313, 1999

Nakagawa K, et al, DNA chip analysis of comprehensive food function: inhibition of angiogenesis and telomerase activity with unsaturated vitamin E, tocotrienol, BioFactors 21; 1-4:5-10, 2004

Ohrvall M, et al, Gamma, but not alpha, tocopherol levels in serum are reduced in coronary heart disease patients J Intern Med, 239:111-7, 1996

Uto-Kondo H, et al., Gamma tocopherol accelerated sodium excretion in a dose dependent manner in rats with a high sodium intake, J Clin Biochem Nutr 41: 211-17, Nov 2007

Uto H, et al, Gamma-tocopherol enhances sodium excretion as a natriuretic hormone precursor, J Nutr Sci Vitaminology 50:277-82, 2004

Kantoci D, et al, Endogenous natriuretic factors 6: the stereochemistry of a natriuretic gamma tocopherol metabolite LLU-a, J Pharmacol Exper Therap 282:648-56, 1997

Murray EED, et al, Endogenous natriuretic factors 7: Biospecificity of a natriuretic gamma tocopherol metabolite LLU-a, J Pharmacol Exper Therap 282 657-62, 1997

Before prescribing treatment, FMU recommends that you follow the standard of care of your profession, as well as confirm the information contained herein with other sources.

Functional medicine embraces the totality of the regulatory functions of the body. It encompasses all of the biophysical, biochemical, enzymatic, endocrine, immunological, and bioenergetic regulatory capacities.

Ronald Grisanti D.C., D.A.B.C.O., D.A.C.B.N., M.S.

Compliments from Functional Medicine University

http://www.functionalmedicineuniversity.com/public/department88.cfm

Ask Dr. Bernstein Tele-Seminar (relating to Type 1 & 2 Diabetics)

Dr. Bernstein is a Type 1 Diabetic who went against the main-stream way of thinking when it came to managing his diabetes. He is and type 1 diabetic endocrinologist with some great information!  Although those who are well versed in functional approaches may have some disagreements with some of his suggestions, overall he is still a wonderful resource especially for Type 1’s!!  I especially love his philosophy that all diabetics are entitled to the same blood sugar levels as non diabetics!

Ask Dr. Bernstein Webcast and Teleconference on, Wednesday, December 28th, you can listen to view the presentation for a limited time by going to this link :

dr.richard.k.bernstein

Watch December Seminar Here

The next webcast is January 25th at 8:00 pm EDT, 7:00 pm CDT, 5:00 pm PDT, and for our overseas guests, 12:00 am UTC (Wednesday).

Put all of the tele-seminar dates for 2017 in your calendar:   January 25th,  February 22nd, March 29th, April 26th, May 31st, June 28th, July 26th, August 30th,  September 27th, October 25th, November 29th, and December 27th, 2017.

If you have a friend who you feel would benefit from listening to the next tele-seminar, they can register here.

Betrayal: Autoimmune Disease, what they aren’t telling you…

This is a great series that delves into looking at health conditions through a functional lens, looking at it from a functional perspective 😉

This is an 7 part series which you can sign up here to get the entire series:

https://betrayalseries.com/episode-1-1nyawjkj2?inf_contact_key=7d0cbc282bdddf41ebe8765a8e30e2913dfccc53967e4ef6635564f98c6380b9

5 Pillars to Healthy Function - Diet - Rest - Stress Management - Exercise - Proper Digestion

5 Pillars of Healthy Function

One of the challenges in functional health is figuring out where to start.  With the approach being different than the symptom management model it can be overwhelming as one attempts to uncover the root causes of the malfunctioning of our body.  Another challenge is looking at our health challenges from the perspective of a healthy body that is no longer in a state of homeostasis.  When our presupposition is our body was designed to function in that state and when it is not functioning as intended then we focus on what factors disrupt the natural balance and which factors promote balance.  So what are some of those things?  And, which of those things take priority?

The top five areas which impact our health the greatest are:

  • Diet
  • Rest
  • Stress
  • Exercise
  • Digestion

How many of us have worked really hard at one or two, maybe even three, of these and we still come up against roadblocks in our journey to good health?  In recent months our physician and I have been looking at the things which are working for my son, what’s not and where can we improve.  Out of these top five we have two of them down pat – knock out of the park grand-slams!  One of these we do ok with, better than the average American and two of them we struggle with – BIG TIME!

So what makes these five things the most important?  Well, they work in harmony. When we take one of these out of the equation things begin to malfunction.  Each of them by themselves directly impact our health. Let’s take a brief look at each one:

Diet

This one is probably the most understood and the one we embrace the most.  What we eat. In every facet of life whether food, vehicles, electronics -the quality of the building blocks have a direct impact on the final product.  When we eat things which are food-like and not real food we are providing low quality building materials for our body to work with.   At some point we will get what we pay for.  Just as we get what we put into our retirement accounts, our health in latter years will be a return on what we invested earlier in life.

Rest

There are several blogs which I follow that have some amazing posts which reflect on our childhood years.  Do you ever remember asking why you needed to take a nap? Why did you have to go to bed so early?  The answer I always received was – that was the time my body repairs, the more I rest the more I will grow.  Of course I couldn’t wait to grow up so that usually motivated me to take that nap or head to bed!

Our bodies need time to rest.  We have a lot of demands for our time and energy.  Just as we don’t leave our vehicles running all the time we shouldn’t keep our bodies running all the time.  They need time to repair from the daily toils from our day to day life.  If we continually ‘burn the candle at both ends’, the wick is going to burn out.  If we keep our engine going without down time it is going to overheat. The same with our bodies – it will start to malfunction.

Stress

This one is HUGE!  I don’t know about you, but I have heard this many times “stress affects your health”.  Yeah, yeah and I shrug it off going about my stressful life… Well, I am not sure I am able to articulate how vital eliminating and reducing stress are to a healthy functioning body.

The best illustration I have is our vehicles again -if we drove it off-road continuously putting stress on the suspension the suspension system is going to fail.   If we ran into curbs every time we park our vehicle it will cause damage.   The kicker is our body has a way to deal with these repairs on a daily basis – the problem is those ‘internal bandages’ can cause more malfunction when we have everything bandaged up!

This is one of those two areas my family, especially myself, struggles with.  The only answer I have found to effectively handle stress is a connection with our Creator.  My spiritual life has impacted my stress where nothing else would help.  Finding the peace from our Creator can do amazing things for our health!

Exercise

This is the second most accepted concept to good health.  Diet and exercise, right?  Isn’t that what everyone says?  Well – it is true!! Well, partially – its those PLUS the other ones listed.  But, lets look at exercise.

Did you know when you exercise your endothelium(lining of the blood vessels) releases nitric oxide?  In 1998 Robert F. Furchgott, Louis J. Ignarro and Ferid Murad were awarded the Nobel Peace prize “for their discoveries concerning nitric oxide as a signalling molecule in the cardiovascular system”.  What does nitric oxide do?  It helps to maintain healthy blood pressure, cholesterol levels, regulating clotting and blood flow, to name a few.  Basically it helps to promote healthy cardiovascular function.  Sort of like having a built in fuel system cleaner in a vehicle – wouldn’t that be neat!!

What happens with our fuel system in our vehicles when it gets dirty?  The engine starts running rough, right?  Sometimes it causes other problems as well.  Our bodies are very similar, if our cardiovascular system is not working as designed, it starts to malfunction.  Exercise promotes a smooth running system.

Digestion

So what if we are eating great foods, amazing sleep, no stress and we exercise regularly – we should be all set to a healthy body right?  Ah there is still another piece of the puzzle which needs to be in place – digestion!  If we are not assimilating the wonderful foods our bodies are not going to have access to the building blocks needed for repairing from daily life.

Again I like the illustration of our vehicles.  If our fuel system has a clog and the gas is unable to get to the spark plugs, the engine is not going to work.  Or if the gas that is getting through but its not flowing at the proper rate, the engine is going to run rough.

Having a properly functioning digestive system is another vital part in achieving that highly sought after homeostasis, referred to as good health.  This one is perhaps one of the most difficult to correct since many processes are intertwined with others.  When our system is disrupted it often seems like trying to get untangled from a spiderweb.  Which often loops back to stress as we attempt to untangle our digestive mess.

So what do we do now? How do we return these areas to a balance which promotes healthy function?

Support.  Surround yourself with others who are supportive in your journey. It is amazing what can be accomplished when you have others to help carry your burdens.  Just remember, we have to share that we have a need for folks to have the opportunity to help  😉

Your comments and questions are always welcome! I hope this is beneficial to you or someone you love! Thanks for stopping by!

 

Common sense

I recently updated the “nuts & bolts” page where I touch on how our bodies provide ‘medicine’ to heal.  There is a LOT more to put on that page but I wanted to start sharing since there is a wealth of information that I hope to put there…

Anyway, I was reviewing a webinar regarding the cardiovascular system and one more of those ‘stop in my track’ moments occurred.  Most of us have probably heard about the “bad cholesterol” and “plaque” build up.  For those who haven’t – LDL cholesterol is termed the bad guy. Too much of it and it will start sticking to the lining of your blood vessels causing plaque.  High blood sugar and high amount of abdominal fat stimulate the body to release plasminogen activator inhibitor 1 (PAI-1) which promotes blood clotting and build up of plaque.

The “ah ha” moment was because I understand the wonderful function of LDL in our bodies – it is necessary for repair and damage.  For example, do you know what high blood sugar does to the body?  It is like glass or sand which makes abrasions along the cell wall. So when we see high LDL it is a sign that something is in need of repair.  In this example of high blood sugar, in essence our amazing body is protecting itself from ourselves!  The body gets a signal to go repair and protect the wall by forming the plaque.  Of course in the long run this is detrimental, but at least it provides us with the opportunity to make changes. ***

So often the focus is on lowering that LDL number rather than looking as to WHY is that number elevated?   Our bodies make most of the LDL that is measured in blood tests, it is making it for a reason! What is the reason it is making it??? Lowering the LDL doesn’t address the underlying malfunction in our body. Such as maybe its high blood sugar causing damage… Do you know how many diabetics are on statin drugs?  It’s alarming!

Do you now what statin drugs do?  Statins are prescription pills which are very effective at lowering levels of LDL.  Guess what the most common side effect is?  Muscle pain.   Is this surprising??  It shouldn’t be, after all when we take away a necessary repair mechanism from our body what is going to happen? Stuff is gonna start showing the wear and tear.  Not just in our blood vessels, but our entire body!  It is no wonder there is an increase in heart attacks despite the effectiveness of statins lowering LDL.

Common sense tells us things could go very, very wrong!  Fortunately, there are more and more who have decided to take a look at health from a different perspective, one that looks at how the body is supposed to function.  Getting clues from how the body reacts to an adverse environment, letting our body be the guide. Pinpointing the reason behind why the body took evasive action. This kind of digging gets me super excited about health!  Totally lights a fire for me to pursue healthy choices and be in harmony with what my body is telling me!  Am I the only one who feels this way?

Well, gonna get back to the webinar, maybe I’ll get me some veggies to snack on 🙂

{***I added some clarification to my original post as it may not have been clear I was referring to high blood sugar as just an example of damage to our bodies}